As terapias com células TCR vencem tumores sólidos – finalmente
Nature Biotechnology, publicado online: 02 de outubro de 2024; doi:10.1038/s41587-024-02435-5A aprovação pela FDA da primeira terapia com células T geneticamente modificadas para o...
Rapid generation of long, chemically modified pegRNAs for prime editing
Anzalone, A. V., Koblan, L. W. & Liu, D. R. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors. Nat. Biotechnol....
Multistate and functional protein design using RoseTTAFold sequence space diffusion
Sequence representationTo apply the diffusion framework in sequence space, a continuous representation of the categorical sequence data is needed. To implement this, we...
Increasing intracellular dNTP levels improves prime editing efficiency
Anzalone, A. V. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature 576, 149–157 (2019).Article
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