Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
Esha Madan, Vignesh Vudatha, Praveen Bhoopathi, Sahil Chaudhary, Kartik Gupta, Keshav C. Gogna, Dongyu Zhang, David P. Turner, Jose Trevino, Arturo P. Saavedra, Robert Winn & Rajan Gogna
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Esha Madan, António M. Palma, Vignesh Vudatha, Amit Kumar, Praveen Bhoopathi, Gaurav Bilolikar, Amy Lu, Sahil Chaudhary, Kartik Gupta, Keshav C. Gogna, Karthikeya Bhoopathi, Padmanabhan Mannangatti, Swadesh Das, Adam M. Hawkridge, Kumari S. Shree, Sambhav Khurana, Dongyu Zhang, Arjun Rijal, Charles Lyons, David P. Turner, Jennifer Koblinski, Andrew S. Poklepovic, Paul B. Fisher, Jose Trevino, Robert Winn & Rajan Gogna
VCU Institute of Molecular Medicine, Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
Esha Madan, António M. Palma, Amit Kumar, Santanu Maji, Padmanabhan Mannangatti, Swadesh Das, Paul B. Fisher & Rajan Gogna
Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
Esha Madan, António M. Palma, Amit Kumar, Gaurav Bilolikar, Anjan K. Pradhan, Santanu Maji, Amy Lu, Karthikeya Bhoopathi, Padmanabhan Mannangatti, Swadesh Das, Kumari S. Shree, Sambhav Khurana, Paul B. Fisher & Rajan Gogna
Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal
António M. Palma, Vignesh Vudatha, Maria Leonor Peixoto, Cláudia L. da Silva & Arsénio M. Fialho
Institute for Lung Health (ILH), Universities Giessen & Marburg Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University Giessen, Giessen, Germany
Jochen Wilhelm
Universities Giessen & Marburg Lung Center, German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany
Jochen Wilhelm, Isabelle Dreier & Michail Yekelchyk
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, USA
Tytus Bernas & Kyoung Jae Won
Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Patrick C. Martin, Hyobin Kim & Daniel Oh
Collegiate School, Richmond, VA, USA
Aenya Gogna
Champalimaud Center for the Unknown, Lisbon, Portugal
Maria Leonor Peixoto, Davide Accardi, Rita C. Marques, Ana Bigio, Sara Belião, Antonio Lopez-Beltran & Eduardo Moreno
Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Thais Fenz Araujo, Elena Garre, Anna Gustafsson & Göran Landberg
Division of Gynecologic Oncology, Department of Obstetrics/Gynecology, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Kalpana Deepa Priya Dorayappan & Karuppaiyah Selvendiran
Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin, Madison, WI, USA
Narsimha Mamidi & Seungpyo Hong
Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA
Zhaoyu Sun & William L. Redmond
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Amalie Lykke Olsen, Lin Lin & Yonglun Luo
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
Amalie Lykke Olsen, Lin Lin & Yonglun Luo
Department of Genetics, Harvard Medical School, Boston, MA, USA
Asaf Ashkenazy Titelman & George M. Church
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA
Asaf Ashkenazy Titelman & George M. Church
Empire Genomics Corp., Depew, NY, USA
Michael Bianchi & Phil Jessmon
Indiana University School of Medicine-Bloomington, Indiana University, Bloomington, IN, USA
Elnaz Abbasi Farid & Kenneth P. Nephew
Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA
Elnaz Abbasi Farid & Kenneth P. Nephew
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Lena Neufeld, Eilam Yeini & Ronit Satchi-Fainaro
Eurofins Panlabs, Inc., St. Charles, MO, USA
Christopher J. Pelham
Molecular Imaging Center, Department of Biomedicine, University of Bergen, Bergen, Norway
Hans Olav Rolfsnes, Frits Alan Thorsen & Rolf Bjerkvig
Department of Biochemistry, School of Veterinary Medicine, Azabu University, Sagamihara, Japan
Masaki Nagane
IMGENEX India Pvt. Ltd., Bhubaneswar, India
K. Gopinath Achary & Javed Akhtar
Centro de Química Estrutural, Institute of Molecular Sciences and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal
Isabel Correia
Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, WI, USA
Michael J. Poellmann, Kaila Javius-Jones & Seungpyo Hong
Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA
Adam M. Hawkridge
Innomics Inc., Cambridge, MA, USA
Sanya Pal
Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK
Emad A. Rakha
Nottingham Breast Cancer Research Centre, School of Medicine, Academic Unit for Translational Medical Sciences, University of Nottingham, Nottingham, UK
Emad A. Rakha
Syd Labs, Inc., Hopkinton, MA, USA
Gaoping Xiao
Department of Internal Medicine, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA
Steven R. Grossman
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Raghavendra Pillappa
Department of Orthopedic Surgery, Virginia Commonwealth University, Richmond, VA, USA
Karanvir Prakash
VCU Division of Nephrology, Virginia Commonwealth University, VCU School of Medicine, Richmond, VA, USA
Gaurav Gupta
PhaseDesign Research, Framingham, MA, USA
Gary L. W. G. Robinson
Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA
Jennifer Koblinski, Hope Richards, Sadia Sayeed & Michael O. Idowu
Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ, USA
Hongjun Wang
Center for Healthcare Innovation, Stevens Institute of Technology, Hoboken, NJ, USA
Hongjun Wang
Abeomics, Inc., San Diego, CA, USA
Gita Singh & Sujay Singh
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA
Sagar Rayamajhi & Andrew K. Godwin
Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA
Manny D. Bacolod
Department of Obstetrics and Gynecology, Virginia Commonwealth University, VCU School of Medicine, Richmond, VA, USA
Katherine P. Klein & David Chelmow
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
Ronit Satchi-Fainaro
Fox Chase Cancer Center Biosample Repository Facility, Philadelphia, PA, USA
Denise Connolly
Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA
Denise Connolly
NORLUX Neuro-Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway
Rolf Bjerkvig
Department of Oncology, Luxembourg Institute of Health (LIH), Strassen, Luxembourg
Rolf Bjerkvig
Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, Key Laboratory of Brain Functional Remodeling, Shandong, China
Rolf Bjerkvig
Virginia Commonwealth University Health, Richmond, VA, USA
Michael O. Idowu
Institute of Pathology, RWTH Aachen University, Aachen, Germany
Mark P. Kühnel & Danny Jonigk
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, Hanover, Germany
Mark P. Kühnel & Danny Jonigk
Department of Pathology, University of Virginia, Charlottesville, VA, USA
Christopher Moskaluk
Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA
Seungpyo Hong
Department of Morphological Sciences, Cordoba University Medical School, Cordoba, Spain
Antonio Lopez-Beltran
Departamento de Patología, Centro Clínico Champalimaud, Lisboa, Portugal
Antonio Lopez-Beltran
Department of Surgery, Cordoba University Medical School, Cordoba, Spain
Antonio Lopez-Beltran
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
Andrew S. Poklepovic
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
Arun Sanyal
MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK
Usha Menon
Penn Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Ronny Drapkin
Kansas Institute for Precision Medicine, University of Kansas Medical Center, Kansas City, KS, USA
Andrew K. Godwin
University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS, USA
Andrew K. Godwin
Institute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
Maximilian Ackermann
Institute of Pathology and Molecular Pathology, Helios University Clinic Wuppertal, University of Witten/Herdecke, Wuppertal, Germany
Maximilian Ackermann
Institute of Medical Genetics and Pathology, University Hospital Basel and University of Basel, Basel, Switzerland
Alexandar Tzankov & Kirsten D. Mertz
Department of Surgery, Division of Surgical Oncology, University of Virginia, Charlottesville, VA, USA
Allan Tsung
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD, USA
David Sidransky
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
David Sidransky
Department of Dermatology, VCU School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
Arturo P. Saavedra
Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, VCU School of Medicine, Virginia Commonwealth University, Richmond, VA, USA
Robert Winn
E. Madan performed experiments, analyzed the data, wrote the manuscript and provided funding and supervision. A.M.P., V.V., A.K. and P.B. performed experiments, prepared the figures, analyzed the data and wrote the manuscript. J.W. performed biostatistical analysis, prepared the figures, analyzed the data and wrote the manuscript. T.B. and D.A. performed microscopy experiments, analyzed and interpreted the data, prepared figures and wrote the manuscript. P.C.M., G.B., M.D.B., I.D., H.K. and D.O. performed biostatistical analysis, helped with interpretation of the data and prepared the figures. A. Gogna and A.B. helped with preparation of figures and live-cell and animation videos. M.L.P., M.Y., D.Z., S.P., S.K., K.B., P.M., I.C., E.A.F., A.K.P., S.M., C.J.P., A.L., M.N., S.C., K.G., K.C.G. and K.S.S. helped with collection of pathology tissue material and interpretation and analysis of pathology data, performed experiments and prepared the figures. T.F.A., E.G., A. Gustafsson, G.L., L.N., E.Y. and R.S.-F. helped with design and performance of 3D scaffold and organoid experiments, data analysis and interpretation. K.D.P.D. helped with PDX experiments and interpretation and analysis of data. N.M., M.J.P., K.J.-J. and S.H. helped with design and performance of exosome biology experiments, writing of the manuscript and data analysis and interpretation. Z.S. and W.L.R. helped with design and performance of multiplexing experiments and with data analysis and interpretation. M.B. and P.J. helped with design and with performance, interpretation and analysis of the FISH experiment. H.O.R., F.A.T. and R.B. helped with MR imaging and with interpretation and analysis of data. K.G.A., J.A., G.X., G.S. and S. Singh helped with design and production of the mAbs. S.D., C.L.d.S., A.M.F., D.T., S.R.G., K.P., G.G., G.L.W.G.R. and H.W. helped with editing of the manuscript. A.M.H., A.R. and C.L. helped with design and performance of mass spec analysis. A.S. and P.B.F. helped with writing of the manuscript and by providing laboratory resources, availability of postdoctoral researchers to collaborate and additional laboratory space. G.M.C., Y.L., A.L.O., L.L. and A.A.T. helped with design, performance, data analysis and interpretation of CRISPR-off experiments. A.S.P., U.M., R.D., A.K.G., K.S. and D. Chelmow helped with collection of surgery and pathology tissue material, helped with PDX models, provided expertise on ovarian cancer, helped with design of biomarker potential of the study and helped with design of therapy protocol for ovarian cancer. R.P., J.K., S.R., H.R., S. Sayeed, K.P.K., D. Connolly, K.P.N., M.O.I., M.P.K., C.M., M.A., A.L.-B., D.J., K.D.M., A. Tzankov, S.B., E.A.R. and R.C.M. helped with collection of surgery and pathology tissue material and helped with interpretation of pathology data. A. Tsung and D.S. helped with collection of surgery material, fostered clinical collaborations and helped with data analysis and interpretation. J.T. helped with mouse tumor models and data interpretation and analysis and provided funding and supervision. A.P.S., R.W., K.J.W. and E. Moreno helped with manuscript writing and data interpretation and analysis and provided funding and supervision. R.G. designed the study experiments, organized all collaborations, analyzed and compiled all the data, wrote the manuscript and provided funding and supervision.
